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For instance, during the course of EAE induced by MOG immunization there is increased oxidative stress in spinal cord OLs characterized by higher levels of lipid peroxidation products, such as MDA and 4-HNE, which could be reversed by the administration of the ferroptosis inhibitor ferrostatin-1 (Fer-1) ( 5.2 Iron and neurons It is already known that there is a crosstalk between neurons and T cells that can result in disease amelioration or progression