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Gradual Results: Full results appear gradually over several weeks to months, improving skin texture, firmness, and volume

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The mid-to-late follicular phase is characterized by a moderately pro-inflammatory milieu that supports follicular maturation and vascularization (e.g., elevated IL-8 and soluble IL-6 receptor), with estradiol promoting a Th2 bias and natural killer (NK) cell cytotoxicity