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Our data thus expand on the Monod–Wyman–Changeux model of allosteric regulation 81 in three ways: (1) the eIF2B oligomer is composed of two copies of five distinct monomers, (2) the binding pocket for eIF2 and the binding pocket for eIF2-P are connected by the allosteric axes, and (3) the experiments with AcP10 provide evidence that eIF2B activation on one side synchronizes the symmetry-related other side of the complex (Supplementary Fig

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