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Through the production of hydroxyl or hydroperoxyl radicals via the Fenton reaction or alkoxyl radicals via Fenton-type reactions, cellular iron accumulation can lead to severe complications in the liver (cirrhosis, hepatocellular carcinoma), the heart (hypertrophy, insufficiency, cardiac arrhythmia) and the endocrine glands (insulin-dependent diabetes) [175,197] (Fig

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JAMA Netw Open 2024;7(11):e2444659