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Dysregulation of interactions between astrocytes and neurons, coupled with inadequate activation of NRF2 in astrocytes, may lead to ferroptosis in neurons, particularly in dopaminergic neurons, and contribute to the disruption of circadian rhythms associated with sleep disturbances (Ishii et al

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Hyperglycaemia-induced stimulation of the polyol pathway and oxidative damage may be critical mechanisms associated with pathological injury [208], [210]

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