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Conclusions The use of newer persister medications or biofilm agents was not evaluated in any of the four prior RCTs for the treatment of persistent symptoms of Lyme disease [136,137,138] or the PLEASE trial, which used doxycycline, clarithromycin, hydroxychloroquine, and IV ceftriaxone [139]

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hippocampal BDNF protein +1.8× confirmed by ELISA at 24h post-behaviour

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