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However, as the chemical structure of ASTX —including the degree of esterification, the type of fatty acid involved, and the presence of cis double bonds—is closely related to the source and influence its biological properties and bioavailability, the therapeutic potential of new resources must be investigated (16)

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However, their long-term efficacy is significantly reduced by intrinsic and acquired resistance, which is why second-line medications like regorafenib, cabozantinib, and ramucirumab are being studied