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Both automatically generate ROIs for each detected Ca 2+ event, making them particularly useful for unbiased event detection, but are incapable of providing information regarding the percentage of cells activated

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NOX also controls the production of pro-inflammatory cytokines interleukin-1-β (IL-1β), and tumor necrosis factor-α (TNFα), which are elevated in the plasma and CSF of ALS patients (Poloni et al., 2000