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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide — highest average weight loss Semaglutide — significant weight loss Tesamorelin — moderate weight loss, primarily through visceral fat reduction AOD-9604 — primarily body composition effects MOTS-c — primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction
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