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Other factors remaining constant, the concentrations of the two forms modulate the effective redox potential of the couple according to the relationship [GSH] 2 /[GSSG] (Meyer, 2008)

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In vitro , upon incubation in the absence or presence of additional oxidative stress, gclm −/− erythrocytes exposed significantly more phosphatidylserine, a cell death marker, than gclm +/+ erythrocytes, an effect at least partially due to increased cytosolic Ca 2+ concentration