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Drug tolerant persister cell plasticity in cancer: a revolutionary strategy for more effective anticancer therapies | Signal Transduction and Targeted Therapy

2 Autophagy: mechanisms and role in pathologies In recent decades, the role of autophagy in pathogenesis has attracted considerable interest as it could provide useful explanations in the evolution of several diseases (14) and its modulation could help to discover new drugs usable in therapy (15)

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Mutations that occurred in genes for these TFs resulted in embryo defects ( MADS78 or MADS79 in rice ( Oryza sativa ) showed aberrations in endosperm biogenesis and double mutants displayed delays in seed development (Figures 2, 4) ( Transcriptomic analyses of medicinal plant species for secondary metabolite synthesis Transcriptomic analyses of medicinal plant species allow valuable comparisons of newly discovered genes with the existing data helping to understand the complexity of secondary metabolite biogenesis from various organs and developmental stages and to determine functions of encoded biomedical proteins (Wang et al., 2020

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