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Comprising six specialized cell lineages, enterocytes (absorptive cells), microfold cells (M cells), goblet cells, Paneth cells, hormone-producing enteroendocrine cells (EECs), and stem cells (Figure 1)

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Therefore, it appears that NADPH oxidase-mediated ROS and systemic inflammation function within a vicious cycle since ROS are responsible for increased pro-inflammatory cytokine expression [199], and TGFβ1 and endothelin1 cytokines appear to increase ROS production by modulating NADPH oxidase activity [63]