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Mutagenicity of Oxoaldehydes Endogenous metabolic processes such as lipid peroxidation and glycolysis can produce oxoaldehydes such as methylglyoxal and glyoxal, which can rapidly cross-react with amino acid side chains and give rise to advanced glycation end products (AGEs)

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However, further experiments revealed that treatment with the glycolysis inhibitor 2-Deoxy-D-glucose (2-DG) did not significantly reduce the levels of G6P or DNA synthesis in KATO-III and MKN-45 cells, whereas these levels were significantly decreased in control cells (Fig