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TLR3 can sense endogenous mRNAs, while TLR4 is activated by HMGB1, fibronectin EDA, tenascin-C, fibrinogen, surfactant protein A/D, β-defensin-3, HSP60, HSP70, HSP22, GP96, S100A8 (MRP8), S100A9 (MRP14), neutrophil elastase, antiphospholipid antibodies, lactoferrin, heparan sulfate fragments, hyaluronic acid fragments, serum amyloid A, oxidized LDL, and saturated fatty acids