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Thus, both superficial and probably also juxtamedullary nephrons contribute to urea secretion, raising urea delivery to ~110% of the filtered load at the level of the cortical collecting ducts

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(3) Fer-1 and deferiprone can inhibit iron-dependent cell death in renal tubular epithelial cells, thereby reducing kidney injury and fibrosis induced by UUO or ischemia-reperfusion (128)