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In addition, aspartame, but not glucose, was shown to increase protein levels of the membrane sweet taste receptor 1 (T1R1) and to decrease protein levels of sweet taste receptor 3 (T1R3), but aspartame did not alter protein levels of sweet taste receptor 2 (T1R2) after exposure at 1 ng/mL for 7 days

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869 One hypothesis is that these residues play multiple roles, one of which is to initiate ligand exchange with the metallochaperone