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Although direct PET evidence in gender-affirming hormone therapy (GAHT) is lacking, brain-related changes associated with GAHT have been demonstrated [127], and converging human and preclinical data suggest that estradiol can increase 5-HT2A receptor expression or availability, whereas testosterone may exert broader modulatory effects on serotonergic systems, although receptor-specific effects remain insufficiently characterized [87, 91, 99]

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[1] Propoxyphene: (Moderate) Use caution when using dexpanthenol with drugs that decrease gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol