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CBP was also reported to interact with Neh4 and Neh5 domains of Nrf2, leading to the acetylation of the Neh1 domain which is responsible for DNA-binding [42]

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The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies

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