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Some drugs, including proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) are acid-inhibiting, impairing the release of dietary B12 from food proteins, thus producing risk of B12 defi­ciency (Lam et al., 2013)

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The approval was backed by data from the CARTITUDE-4 study, where treatment with Carvykti led to “statistically significant and clinically meaningful improvement of progression-free survival compared to two standard of care treatment regimens,” according to the companies