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Strong associations between HbF level and single-nucleotide polymorphisms (SNPs) have been identified for at least four genomic loci, including the HBB (hemoglobin, beta) and olfactory receptor gene clusters on chromosome 11p15.4, the chromosome 6q23.3 HBS1L-MYB (HBS1-like translational GTPase - v-myb avian myeloblastosis viral oncogene homolog) intergenic region (HMIP), the BCL11A (B-cell CLL/lymphoma 11A) locus on chromosome 2p16.1, and the KlF1 (Kruppel-like factor 1) gene on chromosome 19p13.13 [11], [12], [13], [14], [15], [16], [17], [18]
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