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Amgen's MariTide Phase 2 showed no weight loss plateau at 52 weeks (Nov 2024): The absence of a weight loss plateau effect — which both semaglutide and tirzepatide display — would be a clinically meaningful differentiation if confirmed in Phase 3, potentially enabling greater sustained weight loss

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A 2024 study identified the metabolite Ac-LKKTE as showing significantly greater wound-healing activity in fibroblast models than TB-500 alone (Rahaman et al.)

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