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Changes in RORα lead to the inhibition of aging and the expression of the inflammatory factor IL-1α in endothelial cells to protect the cardiovascular system [225], [226]

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In the intestinal-specific Sirt1 KO mice, increased liver inflammation, iron metabolism and lipid peroxidation disorders were observed, accompanied by normalized liver iron death related genes (such as Gpx4 , Acsl4 , and p53 ), thus forming a protective effect on liver injury caused by alcohol (Zhou et al., 2020)