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In addition to the mentioned above, oligomerization of either RAGE or its ligands is one more key mechanism, controlling AGE-RAGE interplay (90)

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In the Old World, Leishmania major is the primary etiological agent of zoonotic cutaneous leishmaniasis, particularly in the Middle East, including Iran, where the reference strain MRHO/IR/75/ER has been widely used in experimental studies due to its well-characterized virulence and reproducibility in BALB/c mouse models 4,5