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(2017) found that Tc ATG8.1 expression and mTOR-dependent autophagy were induced during early stages of metacyclogenesis and showed that spermidine and related polyamines positively regulated autophagy and differentiation of epimastigote to metacyclic trypomastigote form (Vanrell et al., 2017)

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Under hypoxic conditions, cytoplasmic glucose is metabolized into pyruvate through a series of enzymatic reactions