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use of alternative treatment Toxicity-related changes to fluoropyrimidine-based treatment (i.e., dose reduction or increase, treatment delay and discontinuation) Severe fluoropyrimidine-related toxicity, overall and by type (hematological, gastrointestinal, dermatological) Toxicity-related hospitalization Toxicity-related mortality Fluoropyrimidine Treatment Effectiveness Treatment response Disease progression Overall survival Progression-free survival Literature Screening A single reviewer conducted an initial screening of titles and abstracts using Covidence 41 and then obtained the full texts of studies that appeared eligible for review according to the inclusion criteria