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Helping Maintain Skin Hydration and Barrier Integrity Barrier research measures transepidermal water loss and the production of glycosaminoglycans and proteoglycans, which hold water between collagen fibers

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[1] [2] This triple-receptor mechanism distinguishes it from currently approved agents such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GIP/GLP-1 agonist)