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SOD1 is required for the growth of KRAS mutant NSCLC cells in vitro To investigate the molecular function of SOD1 in lung cancer cells, we derived NSCLC cell lines from Sod1 +/+ or Sod1 Flox/Flox KP lung tumors (Fig

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furthermore it can form stable complexes with Mn +2 , Cu +2 , Zn +2 , and Fe +2 , preventing oxidative interactions between these transition metals and biomolecules