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20 There is one early blinded, placebo-controlled trial of NAC on its own in 43 patients with Alzheimer’s disease that found NAC, 50 mg per kg bodyweight (equivalent to 3750 mg for a person weighing 75 kg) per day for 6 months, to be superior to placebo in almost all outcome measures, although not all reached statistical significance

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As a result, the restoration of WIF1 reduced nuclear β -catenin levels and consequently suppressed Wnt signaling (Liu et al., 2011b)