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The innate immune system plays a crucial role in its pathogenesis by mediating early inflammatory responses and facilitating the activation of adaptive immunity, culminating in the execution of melanocyte destruction by CD8 + T cells

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Experimental evidence shows that chronic OS in vitro increases the levels of tau phosphorylation at paired helical filaments (PHF-1) epitope (serine 396/404) via the inhibition of glutathione synthesis by buthionine sulfoximine (201)