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TFH cell Upon activation, naïve T cells differentiate into Teff in the LN, which are promptly dispatched to sites of inflammation to mount an immune response, whereas differentiated TFH cells remain within the lymph nodes or lymphoid follicles, specifically the germinal centers (GCs) (138)

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This creates a harmful cycle - more ROS damages DNA further, which activates PARP1 and uses up more NAD+