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As shown in the section below, SIRT1 also catalyses a range of substrates such as NF-κB, forkhead box class O family member proteins (FOXOs), peroxisome proliferator-activated receptor γ (PPARγ), peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), and P53 [338,339,340]