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It is active in germ cells and stem cells, but suppressed in most normal somatic cells

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PN-943 PN-943 is an oral, gut-restricted, anti-α4ß7 integrin that selectively blocks leukocyte activation and trafficking in the gastrointestinal tract.38 Results of the phase II trial (IDEAL) in patients with UC were presented as an abstract in 2022.39 The 12-week double-blind, placebo controlled trial randomized patients in 1:1:1 ratio to oral PN-943 450 mg twice daily, 150 mg twice daily or placebo