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A facial cream containing GHK-Cu applied for 12 weeks to 71 women with mild to advanced photoaging increased skin density and thickness, reduced laxity, improved clarity and reduced both fine lines and wrinkle depth, compared with control

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These medications have some potential for drowsiness that will make a weak animal even weaker, so it is important to find the dose that relieves pain and improves mobility without making the pet sleepy (which would discourage mobility)