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Recent research indicates that Spirulina supplementation might offer neuroprotective benefits and enhance cognitive performance in neurodegenerative disorders, including Alzheimer's and Parkinson's disease (99, 100)

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extract, i.e., psuedohypericin, amentoflavone, quercetin, and chlorogenic, which acted synergistically, inhibited LPS-induced Prostaglandin E2 (PGE2), TNF and NO production in LPS-activated mouse RAW 264.7 macrophages, through SOCS3 (suppressor of cytokine signaling 3) activation, a part of the toll-like receptors (TLRs) pathway (Hammer et al., in vitro model of systemic inflammation, can be recognized as potential inhibitor of neural inflammation and therefore, may encourage neurogenesis in patients with depression