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In the case of MRD conversion from negative to positive or when a 1log10 elevation occurs as determined by RT-qPCR in patients that were previously stable, the result must be confirmed using a bone marrow sample at least two weeks after.7,85,86 Special situationsAcute promyelocytic leukemia in children APL occurs in 0.06 cases per 100,000 per year in the pediatric population

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