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191,192 However, in the brain of AD patients, factors such as metal accumulation, overexpression of related enzymes (e.g., NADPH oxidase), and mitochondrial dysfunction are involved in producing excessive ROS, surpassing the ability of the endogenous antioxidant system and resulting in an oxidative imbalance

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• In case you don’t know, between January 2018—when I turned 40!—and rather recently I have been deep in the worst time of my life