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Previous studies by our group also observed an increase in ROS in aortas and mesenteric arteries of rats chronically exposed to low doses of mercury (Wiggers et al., 2008) associated with altered COX-2-expression leading increases the expression of the enzyme NADPH oxidase, which stimulates the formation ROS ( Furthermore, ROS stimulates inflammatory cell activation and endothelial dysfunction

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On the safety of Aspergillus niger – a review