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Similarly, total oxidative status (TOS), oxidative stress index (OSI), and urinary 8-isoprostane levels (a non-enzymatic peroxidation product of arachidonic acid) tend to increase after extended or continuous NSW, with concurrent decreases or alterations in total antioxidant capacity (TAC) and total antioxidant status (TAS), highlighting an imbalance in favor of oxidative damage 74,75,76,77

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Additionally, N-acetylcysteine (NAC), an antioxidant precursor to glutathione, has been shown to ameliorate EBV-induced chronic inflammation in preclinical models by reducing leukocyte infiltration and tissue damage