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Moreover, compared to other tumor cell subtypes, Epi_2 is enriched with various tumor progression-related signaling pathways, including epithelial-to-mesenchymal transition pathways associated with metastasis (Figure 2D)

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Probiotics possess strains of Lactobacillus and Bifidobacterium which are potential microorganisms that can restore microbial balance in the gut, ultimately reducing inflammation and improving GI functions, which are often impaired in PD patients (104)