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The reagents used in this study were Etoposide (Selleck Chemicals, S1225), HU (Sigma, H8627), MMS (Sigma,129925-5G), Aphidicolin (Cayman,14007), Cisplatin (Sigma, 479306), Polybrene (Sigma, TR-1003), puromycin (Sigma, P9620), Doxycycline (MCE, NY-N0565B), 4-hydroxytamoxifen (4-OHT) (Sigma, H6278), Shield-1 (CheminPharma, CIP-S1-0005) ViaFect™ Transfection Reagent (Promega, E4981)