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Cancer cells mainly rely on aerobic glycolysis rather than OXPHOS, generating NADPH by activating the pentose phosphate pathway (PPP), adenosine monophosphate-activated protein kinase, and reductive glutamine and folate metabolism to prevent a rapid ROS generation (11,13,14)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Nasrollahzadeh A., Mollaei Tavani S., Arjeh E., Jafari S.M