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In mammalian cells, ROS are essentially produced by enzymes and are from different origins: mainly from the cytoplasmic membrane NADPH oxidase and from the enzyme complex of the mitochondrial respiratory chain, but also from sources of other organelles such as xanthine oxidase (XO), lipo- and cyclo-oxygenase, cytochromes P450 (endoplasmic reticulum) and peroxisomes

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[DOI] [PMC free article] [PubMed] [Google Scholar] Kaarniranta K, Uusitalo H, Blasiak J, Felszeghy S, Kannan R, Kauppinen A, et al