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10.1016/j.bcp.2015.01.009 [DOI] [PMC free article] [PubMed] [Google Scholar] Guo Y., Wu R., Gaspar J

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CD47-SIRPα Checkpoint Inhibition The CD47 protein, frequently overexpressed on malignant cell surfaces, engages with signal regulatory protein alpha (SIRPα) expressed by myeloid cells (particularly macrophages) to transmit an immunosuppressive “don't eat me” signal, enabling tumor immune evasion through phagocytosis inhibition [194]