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What they found (summary): NAD+ levels decline linearly with age in all tissues Sirtuins are “glucose sensors” , activated during caloric restriction and fasting The decline in NAD+ leads to “pseudohypoxia” in aging cells Supplementation with NAD+ precursors in animal models restores sirtuin activity Therapeutic perspectives: NMN, NR, sirtuin activators, CD38 inhibitors Why it matters: This is the reference article for the entire field

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Mashour GA, Frank L, Batthyany A, et al