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Combining current therapies like PDE5 inhibitors with BMPR2 pathway enhancers, AMPK activators, or TGF-β modulators could improve overall treatment outcomes by directly addressing the underlying molecular mechanisms driving the disease

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Moreover, the application of gene editing technologies such as CRISPR-Cas9 may enable a targeted modification of MSCs to enhance their specific therapeutic functions, which will further enhance the effectiveness of MSCs in treating male infertility