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Trafficking of the polycystins to primary cilia is not only demonstrated to be an essential process of the functional maturation of the polycystin complex (with specific calcium-channel activity being recorded in individually patch-clamped cilia), but also their ciliary trafficking has been demonstrated to be essential for preventing cyst formation in the kidney (see also section on trafficking) (Figure 4) Additional membrane-associated subcellular localizations, for PC-1 in particular, were also reported

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