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The importance of SF-1 to the ovarian function can also be illustrated by human mutations in the NR5A1 gene: the mutations cause disorders of premature ovarian insufficiency (POI) thus connecting the dysregulation of SF-1 with low ovarian reserve and infertility (64, 65)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Tainer J.A., Getzoff E.D., Richardson J.S., Richardson D.C