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Importantly, the relevant xanthines (inosine, hypoxanthine and xanthine) all pass the blood-brain-barrier 65,66,67 , and in patients with an HPRT1 deficiency, both plasma and CSF levels of xanthine and hypoxanthine are elevated compared to controls 68,69 , indicating that changes in plasma xanthine abundances may indeed be linked to HPRT1 expression changes in the brain

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