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A few commenters expressed concern that the proposed cost category weight, coupled with potential negative adjustments for the improvement activities and Promoting Interoperability ASM performance categories, would undermine quality improvement and run the risk of incentivizing cost-cutting over clinical quality

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Cells derived from the same patient’s tumor at autopsy showed decreased sensitivity to dabrafenib-trametinib, and increased expression of CD133, consistent with the patient’s lack of response and cancer progression on the drug