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The beneficial effect of EA on POI was thought to be mediated by exciting neurons in the nucleus of the solitary tract (NTS) and activating the vagus efferent nerve pathway to improve GI tract transit, but not by activating the cholinergic anti-inflammatory pathway ( Enterochromaffin Cells Transient receptor potential ankyrin 1 (TRPA1) agonists improve intestinal transit in a mouse model of POI (Tsuchiya et al., 2016)

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This subcutaneous delivery method provides optimal bioavailability and consistent drug release

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